Endocrine Abstracts

Introduction: An 80-year old female with known osteoporosis was reassessed for BMD measurement. Her baseline BMD and T-score of lumbar spine (L1–L4) measured in 2004 were 0.699 g/cm2, −3.5 S.D., T-score of total left hip was 0.618 g/cm2, −2.7 S.D.. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements.Case report: At follow-up...

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...

Objectives: The selective estrogen receptor modulator, raloxifene, exerts a part of its actions through the estrogen receptor alpha activation. We explored if polymorphisms of ESR1 gene modify the effects of 6 months raloxifene treatment on endothelial function.Methods: Two intronic (PvuII and XbaI), and one exonic polymorphism (P325P) of ESR1 were analyzed in 53 postmenopausal women, mean age 59.7+6.2. The flow mediated endothelium ...